Metformin (Glucophage)

About Metformin (Glucophage)

Glucophage contains Metformin, the first-line oral antidiabetic agent for type 2 diabetes mellitus worldwide. It reduces hepatic glucose production, improves insulin sensitivity, and supports weight neutrality or modest weight loss, with a well-established safety record over decades of use.

Benefits of Metformin (Glucophage)

• First-Line Therapy: Recommended by all major diabetes guidelines as the foundation of type 2 diabetes treatment.
• Weight Neutral: Does not cause weight gain and may promote modest weight loss.
• Cardiovascular Benefits: Reduces cardiovascular mortality in overweight type 2 diabetic patients.

How Metformin Works

Metformin activates AMP-activated protein kinase (AMPK) in hepatocytes, suppressing gluconeogenesis and glycogenolysis. It also enhances peripheral insulin sensitivity in skeletal muscle and reduces intestinal glucose absorption, together lowering fasting and postprandial blood glucose levels.

Dosage & Usage

• Dosage: As prescribed; taken with meals to reduce GI side effects. Dose titrated gradually.
• Precautions: Contraindicated in significant renal impairment; withhold before contrast procedures.

Side Effects

• Nausea or diarrhoea (often transient)
• Metallic taste
• Rarely, lactic acidosis in at-risk patients

Consult your doctor before use.